ES02.03 Management of Other Non EGFR Oncogene Addicted Tumors

Comparison of satisfaction with post-operative pain management and level of functional interferance in addicted and non-addicted patients

Introduction: Postoperative pain relief in addicted patients compared with non-addicted patients is often more challenging and they usually suffer from inadequate postoperative pain relief. Objective: The purpose of this study was to compare satisfaction with postoperative pain management in addicted and non-addicted patients and level of pain interference with their functions. Methods: In th...

Systems Biology Modeling Reveals a Possible Mechanism of the Tumor Cell Death upon Oncogene Inactivation in EGFR Addicted Cancers

Despite many evidences supporting the concept of "oncogene addiction" and many hypotheses rationalizing it, there is still a lack of detailed understanding to the precise molecular mechanism underlying oncogene addiction. In this account, we developed a mathematic model of epidermal growth factor receptor (EGFR) associated signaling network, which involves EGFR-driving proliferation/pro-surviva...

Oncogene Overdose: Too Much of a Bad Thing for Oncogene-Addicted Cancer Cells.

Acquired resistance to targeted inhibitors remains a major, and inevitable, obstacle in the treatment of oncogene-addicted cancers. Newer-generation inhibitors may help overcome resistance mutations, and inhibitor combinations can target parallel pathways, but durable benefit to patients remains elusive in most clinical scenarios. Now, recent studies suggest a third approach may be available in...

Sweeter tumors with EGFR

Robo keeps axons moving F or migrating axons, attraction becomes repulsion with the fl ip of an alternatively spliced switch, according to Zhe Chen, Marc Tessier-Lavigne (Genentech Inc., San Francisco, CA), and colleagues. A melange of chemoattractants and repellants guides growing axons to their targets. Axons that cross the midline of the spinal cord on their way toward the nascent brain, how...

Oncogene Addiction in Solid Tumors